New Preparation Method and Application of Prednisolone Sodium Phosphate

The Chemical formula of prednisolone sodium phosphate is C21H27Na2O8P, the molecular weight is 484.39, and the CAS number is 125-02-0. It is also called prednisolone 21-(disodium phosphate). It is easily soluble in water, slightly soluble in ethanol. Its appearance is white powder as the raw material. After being made into medicine, according to prednisolone sodium phosphate medicinal value, there are two manifestations , which are flake solid and liquid. In medicine, it belongs to corticosteroids and glucocorticoids. As a chemical, prednisolone sodium phosphate is widely used. In the paper, I will describe the preparation method, application of prednisolone sodium phosphate , storage condition and packing.

Preparation Method of Prednisolone Sodium Phosphate

Preparation Method of Prednisolone Sodium Phosphate

It is a production technology of prednisolone sodium phosphate, mainly using prednisolone phosphate as raw material,  which is divided into two steps, the steps are as follows:

1.Dissolve prednisolone phosphate with methanol, add purified water after dissolution, add sodium hydroxide solution dropwise to the tank for reaction, control the temperature of the dropwise addition process at 15-30°C, slowly adjust the pH value to 9.2-10, and then Stir it, re-test the pH value unchanged and then filter;

2.Add ethanol in the dilution tank, add the filtrate after the reaction in the first step, stir and separate out a large amount of crystals, discharge after leaving standstill for at least 8 hours, dry the material after cleaning with ethanol, at last , get prednisolone sodium phosphate.

Precautions for the Preparation Method

The milliliter of methanol used in the first step is 4-5 times of prednisolone phosphate gram number. The milliliter number that adds purified water is 4-6 times of prednisolone phosphate gram number. In the first step the pH value is slowly adjusted to 9.5. And the milliliter of ethanol added in the dilution tank in the second step is 15-30 times of prednisolone phosphate gram number.

Advantages of the Preparation Method

1.The method is simple and operational easily.

2.The conditions are mild and safe.

3.The raw materials required for the process of preparation are easy to obtain.

4.The separation is easy.

5.Both material cost and operating cost are low.And this method can obtain prednisolone sodium phosphate that meets pharmaceutical grade requirements.

Applications of Prednisolone Sodium Phosphate

1.Prednisolone sodium phosphate belongs to the class of adrenal corticosteroids. It has various pharmacological effects such as anti-inflammatory, anti-allergic and immune suppression.

2.Prednisolone sodium phosphate is a glucocorticoid. Glucocorticoids can reduce and prevent tissue responses to inflammation, thereby reducing the manifestations of inflammation.

3.Immunosuppressive effects: It can prevent or inhibit cell-mediated immune responses, delay allergic reactions, and relieve the expansion of primary immune responses.

4.Anti-toxin and anti-shock effects: Glucocorticoids can resist the stimulation of bacterial endotoxins on the body, reduce cell damage, and play a role in protecting the body.

5.Prednisolone sodium phosphate is an anti-inflammatory prescription medicine used to relieve swelling caused by a number of diseases, including arthritis, joint pain, psoriasis, colitis (swelling of the colon), leukemia, conjunctivitis (swelling of the surface of the eyes), and Allergies etc.

If corticosteroids are used for a long time, there is a risk of glaucoma (damage to the optic nerve), defects in vision and field of vision, and cataracts in the posterior capsule. So pay attention to it.

The storage conditions and packing of Prednisolone Sodium Phosphate

1.Storage Conditions of Prednisolone Sodium Phosphate

Prednisolone sodium phosphate have to be sealed storage, and be away from moisture. And prednisolone sodium phosphate should be protected from light, avoid damage and moisture absorption, and avoid direct sunlight

2.Packing of Prednisolone Sodium Phosphate

Package Specification is 25 Kg/Drum ,10 Kg/Drum, 5 Kg/Drum, or according to customer requirements.


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