What Are the New Side Effects of Taking Prednisone?

I believe that everyone has used a drug called prednisone when allergic, prednisone anti-inflammatory and anti-allergic effect is strong, then you know what are the side effects of taking prednisone? The following is the related content of the side effects of taking prednisone for you, I hope it will be useful to you!

There was no obvious adverse reaction in the application of physiological dose of glucocorticoid replacement therapy, but the adverse reaction mostly occurred in the application of pharmacological dose, and it was closely related to the course of treatment, dose, drug type, usage and route of administration. Common adverse reactions fall into the following categories.

1.Long-term medication can cause the following side effects

Latrogenic Cushing syndrome visage and posture, weight gain, lower limb edema, Purple lines, prone to bleeding, poor wound healing, acne, menstrual disorders, avascular necrosis of the humerus or femoral head, osteoporosis or fracture (including vertebral compression fractures, pathological fractures of long bones), muscle weakness, muscular atrophy, hypokalemia syndrome, gastrointestinal irritation (nausea, vomiting), pancreatitis, peptic ulcer or intestinal perforation, growth inhibition in children, glaucoma, cataracts Benign intracranial hypertension syndrome, impaired glucose tolerance and aggravated diabetes.

2.The patient can appear mental symptoms

Euphoria, excitement, anxiety, delirium, disorientation, also can show the inhibition. Mental symptoms especially prone in people with chronic wasting disease and in the past had spirit is not normal. The dosage of prednisone 40 mg daily or more, can appear medication for a few days to two weeks.

3.Concurrent infection for glucocorticoids major adverse reactions

Mainly infected with fungi, tuberculosis, staphylococcus, Proteus, pseudomonas aeruginosa and various herpes viruses. It usually occurs during medium or long course therapy, but can also occur after short term use of large doses.

4.Hypothalamic-pituitary-adrenal axis is inhibited

Hypothalamic-pituitary-adrenal axis is inhibited, which is an important complication of hormone therapy, and its occurrence is related to factors such as preparation, dose and course of treatment. When prednisone is used more than 20mg daily for more than 3 weeks, and iatrogenic Cushing syndrome occurs, adrenal function should be considered suppressed.

5.Glucocorticoid after drug withdrawal syndrome can have the following all kinds of different situations:

1) The hypothalamus – pituitary – adrenal function drops

Show is weak, decreased appetite, nausea, vomiting, back pressure on the low side, the long axis of the function recovery after treatment generally need 9 ~ 12 months, functional recovery successively in the order:

The secretion of hypothalamic corticotropin-releasing hormone (CRF) recovered and increased; ACTH secretion recovered and was higher than normal, and the secretion of adrenal corticosterone was still low at this time; The basic secretion of hydrocortin returned to normal, and the secretion of ACTH in the pituitary gland returned to normal from the original excessive; The response of hypothalamic-pituitary-adrenal cortex axis to stress returned to normal.

2)When the drug was stopped, symptoms that had previously been under control reappeared

In order to avoid the occurrence of adrenal cortical dysfunction and the recurrence of the original disease symptoms, the dosage should be slowly and gradually reduced after long-term hormone therapy, and from the original several times a day, it should be taken once a day in the morning, or once the next morning.

3)Glucocorticoid withdrawal syndrome

Sometimes patients with dizziness, fainting tendency, abdominal or back pain, low fever, loss of appetite, nausea, vomiting, muscle or joint pain, headache, fatigue, weakness after discontinuation of the drug can be considered as glucocorticoid dependence syndrome if they can rule out adrenocortical dysfunction and the recurrence of the original disease. Weight gain, hirsutism, acne, increased blood sugar, blood pressure and eye pressure, water and sodium retention. Can cause hypokalemia, excitement, gastrointestinal ulcers and even bleeding perforation, osteoporosis, poor wound healing. The product inhibits antigenic antibody reaction, inhibits leukocyte migration and phagocytosis, and weakens the body’s defense function against external infection.


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